Reactive species
Human; Mouse;Rat
Antibody type
Monoclonal antibodies
Protein name
Phospho-GSK3β(Ser9)
Immunogen
Synthesized peptide derived from human Phospho-GSK3β(Ser9)
Specificity
This antibody detects endogenous levels of Phospho-GSK3β(Ser9) at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.91% sodium azide.
Dilution rate
IHC-p1:50-200 ,WB 1:1000-2000
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Other name
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Background
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Function
catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate
