Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant Wnt3a protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Wnt3a and Wnt3.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
MGC119418 ;MGC119419 ;MGC119420 ;Protein Wnt 3a Precursor ;Protein Wnt-3a ;Wingless type MMTV integration site family member 3A ;Wnt 3a ;wnt3a ;WNT3A protein ;WNT3A_HUMAN.
Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008],
Function
function:Ligand for members of the frizzled family of seven transmembrane receptors.,function:Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN.,tissue specificity:Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.,
