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WDR77 mouse mAb

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WDR77 mouse mAb

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Product code: YP-Ab-04482

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Mouse;Rat

Applications

WB;ICC

Antibody type

Monoclonal antibodies

Gene Name

mep50/wdr77

Protein name

Dalton（DA）

42kD

Immunogen

Purified recombinant human WDR77 protein fragments expressed in E.coli.

Specificity

This antibody detects endogenous levels of WDR77 and does not cross-react with related proteins.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Monoclonal, Mouse

Dilution rate

wb dilution 1:1000 icc dilution 1:100

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Concentration

mg/ml

Stockpile

-20°C/1 year

Other name

2610312E17Rik;Androgen receptor cofactor p44;C79984;HKMT1069;MEP 50;MEP-50;MEP50; MEP50_HUMAN;Methylosome protein 50;MGC2722;Nbla10071;p44;p44/Mep50;RGD1310479;RP11 552M11.3;WD repeat containing protein 77;WD repeat domain 77;WD repeat-containing protein 77;WDR77.

Background

The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],

Function

developmental stage:Expressed in Leydig cells during fetal testicular development, especially during the second semester. Germ cells expression is detected as early as 10 weeks of gestation.,function:Component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation.,similarity:Contains 5 WD repeats.,subcellular location:Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.,subunit:Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

WDR77 mouse mAb

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WDR77 mouse mAb

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Background information

FAQ

Experimental scheme

IP

WB

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