Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human RanBP9 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of RanBP9 and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:1000 icc 1:300
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
cell antigen receptor Ig beta associated protein 1;BPM 90;BPM L;BPM-L;BPM90;BPML;IBAP 1;Imp 9;Importin 9;Novel centrosomal protein RanBPM;RAN binding protein 9;Ran binding protein centrosomal;Ran Binding Protein in the Microtubule organizing center;Ran binding protein M;Ran BP9; Ran-binding protein 9;Ran-binding protein M;RANB9_HUMAN;RanBP 7;RANBP 9;RanBP7;RanBP9;RanBPM.
Background
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008],
Function
caution:According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in microtubule assembly, but other authors infirmed these results in (PubMed:11470507).,domain:The SPRY domain mediates the interaction with MET, AR, and CDC2L1.,function:May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated in response
