Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human PP1C protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of PP1C and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform; Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
Background
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,miscellaneous:Microcystin toxin is bound to Cys-273 through a thioether bond.,online information:The things we forget -Issue 32 of March 2003,similarity:Belon
