Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
TBC1 domain family member 3
Immunogen
The antiserum was produced against synthesized peptide derived from human TBC1D3. AA range:481-530
Specificity
TBC1D3A/B/C Polyclonal Antibody detects endogenous levels of TBC1D3A/B/C protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
TBC1D3; PRC17; TBC1D3A; TBC1 domain family member 3; Prostate cancer gene 17 protein; Protein TRE17-alpha; Rab GTPase-activating protein PRC17; TBC1D3B; TBC1D3I; TBC1 domain family member 3B; TBC1D3C; TBC1D3D; TBC1 domain family member 3C
Background
This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],
Function
disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,
