Reactive species
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Protein phosphatase 1 regulatory subunit 14D
Immunogen
The antiserum was produced against synthesized peptide derived from human PPP1R14D. AA range:66-115
Specificity
PPP1R14D Polyclonal Antibody detects endogenous levels of PPP1R14D protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PPP1R14D; GBPI; Protein phosphatase 1 regulatory subunit 14D; Gastrointestinal and brain-specific PP1-inhibitory protein 1; GBPI-1
Background
Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010],
Function
function:Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,PTM:Phosphorylated on several residues.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in colon, intestine, kidney and brain cortex.,
