Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
E3 ubiquitin-protein ligase HECW2
Immunogen
The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530
Specificity
NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
HECW2; KIAA1301; NEDL2; E3 ubiquitin-protein ligase HECW2; HECT; C2 and WW domain-containing protein 2; NEDD4-like E3 ubiquitin-protein ligase 2
Background
function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,
Function
function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,
