Reactive species
Human;Mouse;Rat
Applications
IHC;IF;WB;ELISA
Antibody type
Polyclonal Antibody
Protein name
Protein NDRG2
Immunogen
Synthesized peptide derived from NDRG2 . at AA range: 10-90
Specificity
NDRG2 Polyclonal Antibody detects endogenous levels of NDRG2 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
NDRG2; KIAA1248; SYLD; Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Syld709613
Background
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],
Function
developmental stage:Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.,disease:Found in pathological brain lesions of Alzheimer disease.,disease:Not expressed or strongly down-regulated in various cancer types, such as astrocytoma, meningioma, liver cancer and pancreatic cancer.,function:May be involved in dendritic cell and neuron differentiation. May have anti-tumor activity.,similarity:Belongs to the NDRG family.,subcellular location:Perinuclear in neurons.,tissue specificity:Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Generally not expressed in tumor cell lines. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein leve
