Reactive species
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Protein phosphatase inhibitor 2
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human IPP-2 (phospho Ser44)
Specificity
Phospho-IPP-2 (S44) Polyclonal Antibody detects endogenous levels of IPP-2 protein only when phosphorylated at S44.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2
Background
Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
Function
function:Inhibitor of protein-phosphatase 1.,PTM:Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.,similarity:Belongs to the protein phosphatase inhibitor 2 family.,subunit:Heterodimer with PP1.,