Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human IMP3 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of IMP3 and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
Cancer/testis antigen 98;CT98;DKFZp686F1078;hKOC;IF2B3_HUMAN;IGF II mRNA binding protein 3;IGF-II mRNA-binding protein 3;IGF2 mRNA binding protein 3;IGF2 mRNA-binding protein 3;IGF2BP3;IMP 3;IMP-3;Insulin like growth factor 2 mRNA binding protein 3;Insulin-like growth factor 2 mRNA-binding protein 3;KH domain containing protein overexpressed in cancer;KH domain-containing protein overexpressed in cancer;KOC 1;KOC1;VICKZ 3;VICKZ family member 3;VICKZ3.
Background
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008],
Function
disease:Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.,function:RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.,similarity:Belongs to the RRM IMP/VICKZ family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,similarity:Contains 4 KH domains.,subcellular location:Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.,subunit:Homodimer and multimer.,tissue specificity:Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fe
