Reactive species
Human;Mouse;Rat
Antibody type
Monoclonal antibodies
Protein name
Telomerase Cajal body protein 1
Immunogen
Purified recombinant human WDR79 protein fragments expressed in E.coli.
Specificity
WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein.
Constitute
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Dilution rate
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Purification process
Affinity purification
Other name
WRAP53; TCAB1; WDR79; Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53
Background
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011],
Function
DNA metabolic process, telomere organization, telomere assembly, telomere formation via telomerase, positive regulation of catalytic activity, positive regulation of molecular function, chromosome organization, regulation of transferase activity, positive regulation of transferase activity, regulation of telomerase activity, positive regulation of telomerase activity,
