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MTHFR Monoclonal Antibody

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MTHFR Monoclonal Antibody

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Product code: YP-Ab-03413

Promotional price: $ 255

100UL 53UL 10UL

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Reactive species

Human;Rat

Applications

WB;IHC;IF;ELISA

Antibody type

Monoclonal antibodies

Gene Name

MTHFR

Protein name

Methylenetetrahydrofolate reductase

Dalton（DA）

Immunogen

Purified recombinant fragment of human MTHFR expressed in E. Coli.

Specificity

MTHFR Monoclonal Antibody detects endogenous levels of MTHFR protein.

Constitute

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Source

Monoclonal, Mouse

Dilution rate

WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200

Purification process

Affinity purification

Concentration

Stockpile

-20°C/1 year

Other name

MTHFR; Methylenetetrahydrofolate reductase

Background

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009],

Function

catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leadin

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

MTHFR Monoclonal Antibody

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MTHFR Monoclonal Antibody

Product introduction

Product Details

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Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

Antibody customization service

ELISA service

Protein service

Biochemical testing services

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