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Fibrinogen β Monoclonal Antibody

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Fibrinogen β Monoclonal Antibody

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Product code: YP-Ab-03396

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human

Applications

WB;ELISA

Antibody type

Monoclonal antibodies

Gene Name

FGB

Protein name

Fibrinogen beta chain

Dalton（DA）

Immunogen

Purified recombinant fragment of human Fibrinogen β (aa30-300) expressed in E. Coli.

Specificity

Fibrinogen β Monoclonal Antibody detects endogenous levels of Fibrinogen β protein.

Constitute

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Source

Monoclonal, Mouse

Dilution rate

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification process

Affinity purification

Concentration

Stockpile

-20°C/1 year

Other name

FGB; Fibrinogen beta chain

Background

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],

Function

disease:Defects in FGB are a cause of congenital afibrinogenemia [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.,disease:Defects in FGB are a cause of thrombophilia.,domain:A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.,function:Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.,online information:Fibrinogen entry,online information:The Singapore human mutation and polymorphism database,PTM:Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fib

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Fibrinogen β Monoclonal Antibody

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Fibrinogen β Monoclonal Antibody

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

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