Reactive species
Human;Mouse;Rat
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Unconventional myosin-VI
Immunogen
Synthesized peptide derived from Myosin VI . at AA range: 40-120
Specificity
Myosin VI Polyclonal Antibody detects endogenous levels of Myosin VI protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/5000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6
Background
myosin VI(MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],
Function
disease:Defects in MYO6 are the cause of non-syndromic sensorineural deafness autosomal dominant type 22 (DFNA22) [MIM:606346]. DFNA22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness.,disease:Defects in MYO6 are the cause of non-syndromic sensorineural deafness autosomal recessive type 37 (DFNB37) [MIM:607821].,disease:Defects in MYO6 are the cause of sensorineural deafness with hypertrophic cardiomyopathy (DFNHCM) [MIM:606346].,domain:Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-b
