Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Ubiquitin carboxyl-terminal hydrolase 45
Immunogen
The antiserum was produced against synthesized peptide derived from human USP45. AA range:301-350
Specificity
USP45 Polyclonal Antibody detects endogenous levels of USP45 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
USP45; Ubiquitin carboxyl-terminal hydrolase 45; Deubiquitinating enzyme 45; Ubiquitin thioesterase 45; Ubiquitin-specific-processing protease 45
Background
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.,
