Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Telomeric repeat-binding factor 2-interacting protein 1
Immunogen
The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252
Specificity
RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
TERF2IP; DRIP5; RAP1; PP8000; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homol
Background
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],
Function
function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TE
