Reactive species
Human;Mouse;Rat
Applications
WB;ELISA;IHC
Antibody type
Polyclonal Antibody
Protein name
Prostacyclin synthase
Immunogen
Synthesized peptide derived from the C-terminal region of human PGI2 synthase.
Specificity
PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.,cofactor:Heme group.,function:Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).,online information:CYP8A1 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.,
