Reactive species
Human;Mouse;Rat
Applications
WB;ELISA;IHC
Antibody type
Polyclonal Antibody
Protein name
Prostaglandin E synthase
Immunogen
The antiserum was produced against synthesized peptide derived from human PGE synthase. AA range:30-79
Specificity
PGE synthase Polyclonal Antibody detects endogenous levels of PGE synthase protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
PTGES; MGST1L1; MPGES1; PGES; PIG12; Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
Background
prostaglandin E synthase(PTGES) Homo sapiens The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.,induction:By TP53/p53.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,
