Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Nuclease EXOG mitochondrial
Immunogen
The antiserum was produced against synthesized peptide derived from human ENDOGL1. AA range:171-220
Specificity
Endo G-L1 Polyclonal Antibody detects endogenous levels of Endo G-L1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
EXOG; ENDOGL1; ENDOGL2; ENGL; Nuclease EXOG; mitochondrial; Endonuclease G-like 1; Endo G-like 1
Background
This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009],
Function
cofactor:Divalent metal cations.,function:Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity.,miscellaneous:The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.,similarity:Belongs to the DNA/RNA non-specific endonuclease family.,subunit:Homodimer.,tissue specificity:Ubiquitous.,
