Reactive species
Human;Rat;Mouse;
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from ADAMDEC1 . at AA range: 10-90
Specificity
ADAMDEC1 Polyclonal Antibody detects endogenous levels of ADAMDEC1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
ADAMDEC1; ADAM DEC1; A disintegrin and metalloproteinase domain-like protein decysin-1; ADAM-like protein decysin-1
Background
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008],
Function
cofactor:Binds 1 zinc ion per subunit.,function:May play an important role in the control of the immune response and during pregnancy.,induction:Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by lipopolysaccharide (LPS). Up-regulated by 1 alpha, 25 dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.,
