Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Neuronal PAS domain-containing protein 1
Immunogen
The antiserum was produced against synthesized peptide derived from human NPAS1. AA range:445-494
Specificity
Neuronal PAS1 Polyclonal Antibody detects endogenous levels of Neuronal PAS1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
NPAS1; BHLHE11; MOP5; PASD5; Neuronal PAS domain-containing protein 1; Neuronal PAS1; Basic-helix-loop-helix-PAS protein MOP5; Class E basic helix-loop-helix protein 11; bHLHe11; Member of PAS protein 5; PAS domain-containing protein 5
Background
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008],
Function
function:May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT.,
