Reactive species
Human;Mouse
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
CGG triplet repeat-binding protein 1
Immunogen
The antiserum was produced against synthesized peptide derived from human CGGBP1. AA range:41-90
Specificity
CGGBP1 Polyclonal Antibody detects endogenous levels of CGGBP1 protein.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
CGGBP1; CGGBP; CGG triplet repeat-binding protein 1; CGG-binding protein 1; 20 kDa CGG-binding protein; p20-CGGBP DNA-binding protein
Background
CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM, Mar 2008],
Function
developmental stage:Expressed in fetal brain and kidney. Lower expression in fetal liver and lung.,function:Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.,miscellaneous:Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,tissue specificity:Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.,
