Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
c-Jun (Phospho Ser249); Transcription factor AP-1;jun;c-jun；AP-1
Immunogen
Synthesized peptide derived from human c-Jun (Phospho Ser249)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat c-Jun (Phospho Ser249)
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39)
Background
function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,
Function
protein import into nucleus, translocation, response to reactive oxygen species, angiogenesis, blood vessel development, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, response to molecule of bacterial origin,regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, cellular ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, apoptosis, response to oxidative stress, mitochondrion organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway
