Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Toll-like receptor 1
Immunogen
Recombinant Protein of TLR1
Specificity
The antibody detects endogenous TLR1 protein.
Constitute
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC: 1:200-500. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
TLR1; KIAA0012; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008],
Function
function:Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds MYD88 (via TIR domain) (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.,tissue specificity:Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.,
