Reactive species
Human;Monkey
Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human STAT1 protein fragments expressed in E.coli
Specificity
This antibody detects endogenous levels of total STAT1 and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
Signal transducer and activator of transcription 1 91kD;DKFZp686B04100;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046; OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1 alpha/beta;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1, 91kD; Signal transducer and activator of transcription 1-alpha/beta;Signal Transductor and Activator of Transcription 1;STAT 1;STAT 91;Stat1; STAT1_HUMAN;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84.
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
Function
disease:Defects in STAT1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas
