Reactive species
Human;Mouse;Rat
Antibody type
Monoclonal antibodies
Immunogen
Purified recombinant human Musashi-1 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Musashi-1 and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Other name
MSI1;Musashi-1;Msi 1;Msi1;MSI1H_HUMAN;Musashi homolog 1;Musashi-1;Musashi1;RNA binding protein Musashi homolog 1;RNA-binding protein Musashi homolog 1.
Background
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008],
Function
domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.,
