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HDAC3 mouse mAb

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HDAC3 mouse mAb

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Product code: YP-Ab-01091

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Mouse;Rat

Applications

Antibody type

Monoclonal antibodies

Gene Name

hdac3

Protein name

Dalton（DA）

49kD

Immunogen

Purified recombinant human HDAC3 protein fragments expressed in E.coli.

Specificity

This antibody detects endogenous levels of HDAC3 and does not cross-react with related proteins.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Monoclonal, Mouse

Dilution rate

wb 1:1000

Purification process

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Concentration

mg/ml

Stockpile

-20°C/1 year

Other name

HD 3;HD3;HDAC 3;HDAC3;HDAC3_HUMAN;Histone deacetylase 3 (HD3) (RPD3-2);histone deacetylase 3;RPD 3;RPD3 2;RPD3;RPD3-2;SMAP 45;SMAP45.

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008],

Function

catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.,PTM:Sumoylated in vitro.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Intera

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

HDAC3 mouse mAb

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HDAC3 mouse mAb

Product introduction

Product Details

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Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

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