Home / Products / Monoclonal antibody /

hnRNP U mouse mAb

Citation (0) Contact
Product code: YP-Ab-01085
Promotional price:

Product introduction

Reactive species
Human
Applications
WB
Antibody type
Monoclonal antibodies
Gene Name
hnrnpu
Protein name
Dalton（DA）
110kD
Immunogen
Purified recombinant human hnRNP U protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of hnRNP U and does not cross-react with related proteins.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Monoclonal, Mouse
Dilution rate
wb 1:1000
Purification process
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration
mg/ml
Stockpile
-20°C/1 year
Other name
Heterogeneous nuclear ribonucleoprotein U;hnRNP U protein;HNRNPU;hnRNPU protein;HNRPU; HNRPU_HUMAN;p120;p120 nuclear protein;SAF A;SAF-A;SAFA;Scaffold attachment factor A;U21.1.
Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the
Function
function:Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Bind to double- and single-stranded DNA and RNA.,PTM:Arg-732 and Arg-738 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Extensively phosphorylated.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 SAP domain.,subcellular location:Component of ribonucleosomes. Also found associated with the cell surface.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1,

Open

Product Details

Customer data and reviews (0)

Fold content

Citation (0)

Fold content

FAQ

Fold content

Experimental scheme

Fold content
>