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CTCF Monoclonal Antibody

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CTCF Monoclonal Antibody

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Product code: YP-Ab-00964

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Monkey

Applications

WB;ELISA

Antibody type

Monoclonal antibodies

Gene Name

CTCF

Protein name

Transcriptional repressor CTCF

Dalton（DA）

Immunogen

Purified recombinant fragment of human CTCF expressed in E. Coli.

Specificity

CTCF Monoclonal Antibody detects endogenous levels of CTCF protein.

Constitute

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Source

Monoclonal, Mouse

Dilution rate

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification process

Affinity purification

Concentration

Stockpile

-20°C/1 year

Other name

CTCF; Transcriptional repressor CTCF; 11-zinc finger protein; CCCTC-binding factor; CTCFL paralog

Background

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been

Function

function:Transcriptional repressor binding to promoters of vertebrate c-myc gene. Also binds to the PLK and PIM1 promoters. May prevent the access of transcriptional activators to enhancers. Also acts as a transcriptional activator of APP. Involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Seems to act as tumor suppressor.,similarity:Belongs to the CTCF zinc-finger protein family.,similarity:Contains 11 C2H2-type zinc fingers.,subunit:Interacts with CHD8.,tissue specificity:Ubiquitous. Absent in primary spermatocytes.,

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

CTCF Monoclonal Antibody

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CTCF Monoclonal Antibody

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Product Details

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Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

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