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BMAL1 Monoclonal Antibody

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BMAL1 Monoclonal Antibody

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Product code: YP-Ab-00956

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human

Applications

WB;IHC;IF;ELISA

Antibody type

Monoclonal antibodies

Gene Name

ARNTL

Protein name

Aryl hydrocarbon receptor nuclear translocator-like protein 1

Dalton（DA）

Immunogen

Purified recombinant fragment of human BMAL1 expressed in E. Coli.

Specificity

BMAL1 Monoclonal Antibody detects endogenous levels of BMAL1 protein.

Constitute

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Source

Monoclonal, Mouse

Dilution rate

WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200

Purification process

Affinity purification

Concentration

Stockpile

-20°C/1 year

Other name

ARNTL; BHLHE5; BMAL1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein

Background

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

Function

alternative products:Additional isoforms seem to exist,function:ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,miscellaneous:CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity.,PTM:Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression.,PTM:Phosphorylated upon dimerization with CLOCK.,PTM:Sumoylated on Lys-259 upon dimerization with CLOCK.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

BMAL1 Monoclonal Antibody

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BMAL1 Monoclonal Antibody

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

Antibody customization service

ELISA service

Protein service

Biochemical testing services

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