Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
FOXA1/FOXA2/FOXA3
Protein name
Hepatocyte nuclear factor 3-alpha/Hepatocyte nuclear factor 3-beta/Hepatocyte nuclear factor 3-gamma
Immunogen
The antiserum was produced against synthesized Acetyl-peptide derived from human FOXA1 around the Acetylation site of Lys265. AA range:231-280
Specificity
Acetyl-HNF-3α/β/γ (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3α/β/γ protein only when acetylated at K264/253/211.
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
FOXA1; HNF3A; TCF3A; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; Forkhead box protein A1; Transcription factor 3A; TCF-3A; FOXA2; HNF3B; TCF3B; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B;Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA3; HNF3G; TCF3G; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G; TCF-3G
Background
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008],
Function
function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,
