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Tuberin/TSC2 (phospho-Ser664) rabbit pAb

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Tuberin/TSC2 (phospho-Ser664) rabbit pAb

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Product code: YP-Ab-00286

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Rat;Mouse;

Applications

Antibody type

Polyclonal Antibody

Gene Name

TSC2 TSC4

Protein name

Tuberin/TSC2 (Ser664)

Dalton（DA）

200kD

Immunogen

Synthesized phosho peptide around human Tuberin (Ser664)

Specificity

This antibody detects endogenous levels of Human Tuberin/TSC2 (phospho-Ser664)

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Polyclonal, Rabbit,IgG

Dilution rate

WB 1:1000-2000

Purification process

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

Tuberin (Tuberous sclerosis 2 protein)

Background

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function

alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Tuberin/TSC2 (phospho-Ser664) rabbit pAb

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Tuberin/TSC2 (phospho-Ser664) rabbit pAb

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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