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Mcl-1 (phospho-Thr163) rabbit pAb

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Mcl-1 (phospho-Thr163) rabbit pAb

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Product code: YP-Ab-00274

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Rat;Mouse;

Applications

WB;ELISA;IHC

Antibody type

Polyclonal Antibody

Gene Name

MCL1 BCL2L3

Protein name

Mcl-1 (Thr163)

Dalton（DA）

About 40kd in human,39kd in mouse and rat

Immunogen

Synthesized phosho peptide around human Mcl-1 (Thr163)

Specificity

This antibody detects endogenous levels of Human Mcl-1 (phospho-Thr163)

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Polyclonal, Rabbit,IgG

Dilution rate

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Purification process

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)

Background

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010],

Function

function:Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.,induction:Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during retinoic acid-induced differentiation.,PTM:Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.,PTM:Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.,PTM:Rapidly degraded in the abs

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Mcl-1 (phospho-Thr163) rabbit pAb

Product navigation

Mcl-1 (phospho-Thr163) rabbit pAb

Product introduction

Product Details

Customer data and reviews (0)

Citation

Background information

FAQ

Experimental scheme

IP

WB

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