Home / Products / Polyclonal antibody /

PEA-15 (phospho Ser104) Polyclonal Antibody

Product navigation

PEA-15 (phospho Ser104) Polyclonal Antibody

Citation (0) Contact

Product code: YP-Ab-00200

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Mouse;Rat;Monkey

Applications

WB;IHC;IF;ELISA

Antibody type

Polyclonal Antibody

Gene Name

PEA15

Protein name

Astrocytic phosphoprotein PEA-15

Dalton（DA）

19kD

Immunogen

The antiserum was produced against synthesized peptide derived from human PEA-15 around the phosphorylation site of Ser104. AA range:70-119

Specificity

Phospho-PEA-15 (S104) Polyclonal Antibody detects endogenous levels of PEA-15 protein only when phosphorylated at S104.

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Polyclonal, Rabbit,IgG

Dilution rate

WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200

Purification process

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

PEA15; Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED

Background

phosphoprotein enriched in astrocytes 15(PEA15) Homo sapiens This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function

function:Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.,PTM:Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.,similarity:Contains 1 DED (death effector) domain.,subcellular location:Associated with microtubules.,subunit:Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.,tissue specificity:Ubiquitously expressed. Mo

Open

Product Details

Customer data and reviews (0)

Fold content

Citation (0)

Fold content

Background information

FAQ

Fold content

Experimental scheme

Fold content

IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

PEA-15 (phospho Ser104) Polyclonal Antibody

Product navigation

PEA-15 (phospho Ser104) Polyclonal Antibody

Product introduction

Product Details

Customer data and reviews (0)

Citation (0)

Background information

FAQ

Experimental scheme

IP

WB

Primary antibodies

Secondary antibodies

Elisa Kit

Biochemical kit

Recombinant protein

Antibody customization service

ELISA service

Protein service

Biochemical testing services

Literature search

Antibody application technology resources

ELISA application technology resources

Research strategies and research tools

Product literature citation

About Us

Recruit

News

Contact

Technical FAQ