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Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

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Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

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Product code: YP-Ab-00029

Promotional price: $ 255

100UL 53UL 10UL

Product introduction

Reactive species

Human;Mouse;Rat

Applications

WB;ELISA

Antibody type

Polyclonal Antibody

Gene Name

CASP6 MCH2

Protein name

CleavedCaspase6p11

Dalton（DA）

33kD

Immunogen

Synthesized peptide derived from Cleaved-Caspase-6 p11 (A194) . at AA range: 150-230

Specificity

Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-6 p11

Constitute

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source

Polyclonal, Rabbit,IgG

Dilution rate

WB 1:500-2000, ELISA 1:10000-20000

Purification process

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Stockpile

-20°C/1 year

Other name

caspase 6, apoptosis-related cysteine peptidase

Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015],

Function

catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.,enzyme regulation:Activation is suppressed by phosphorylation at Ser-257.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.,PTM:Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.,

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IP

常规Immunoprecipitation（免疫沉淀 IP）实验操作步骤

WB

蛋白免疫印迹（WB) 实验步骤

Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

Product navigation

Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

Product introduction

Product Details

Customer data and reviews (0)

Citation (0)

Background information

FAQ

Experimental scheme

IP

WB

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